We are extremely pleased to announce that the first paper from the ULTRADIAN project has finally published!

You can read the University of Bristol press release here.

Find a link to the published paper here

 

The Addison’s Disease Self Help Group recently published a story about the ULTRADIAN study including a report from a patient with Addison’s disease who took part

You can find out more by clicking on the links below:

Research with U-RHYTHM:

www.addisonsdisease.org.uk/blog/behind-the-research-u-rhythm

Participating in ULTRADIAN as a patient with Addison’s:

www.addisonsdisease.org.uk/blog/suzannes-story-participation-in-the-ultradian-study

A long delay since the last update. The pandemic has had a major impact on our ability to complete ULTRADIAN. However we are now finally able to concentrate on the data analysis and we are now actively preparing the first manuscript describing healthy normal variation.

Hopefully more to follow soon!

 

After more than 4 years since it was first conceived, the ULTRADIAN study has reached the end of its recruitment period. There is still much to be done with hundreds of hormone profiles to be processed, reviewed and analysed.

We’ll keep you up to date here with developments including any media releases, publications and meetings. Watch this space!

Its been a while since the last blog post but in the meantime things have been very busy with the project. A 6 month project extension was granted by the EU funding body allowing recruitment to continue until early 2020.

As of today, over 200 healthy volunteers have been successfully sampled, along with almost 50 patients with Cushing’s, more than 30 with primary adrenal insufficiency (Addison’s) and almost 60 patients with primary hyperaldosteronism.

An enormous amount of data is being generated and this takes time to be analysed. At the moment we are working on the validation and data checks whilst developing classifier algorithms based on advanced mathematical and machine learning techniques. A demonstration of the discriminator algorithm for Cushing’s disease is being presented in poster form at the annual SfE BES Endocrinology meeting in Brighton. The poster will be made available here shortly afterwards.

Next update soon…

 

Academic researchers and commercial partners presented their novel work on hormonal diseases and endocrine monitoring at the ULTRADIAN conference in Bergen during the final week of August 2019.

https://www.uib.no/en/med/129339/developing-new-methods-monitor-biological-rhythms

It was a great couple of days with excellent presentations from both the invited speakers and ULTRADIAN researchers who presented a first glimpse of data from both healthy volunteers, and patients with Cushing’s, Addison’s and primary aldosteronism.

Focus over the next few months will be on completing recruitment of all healthy volunteers and patients. Data will be analysed using a variety of methods including a custom set of statistical, mathematical and machine learning techniques designed specifically for the project. Keep following this blog at @ultradian2020 on Twitter for more information!

 

Cortisol effects on brain activity & cognition (CEBAC) Study

This is part of a long term research project looking at the biological impact of the stress hormones cortisol, on brain activity and cognition.

Visit the CEBAC page for more information!

 

The ULTRADIAN consortium is looking forward to hosting delegates at the upcoming “Biological rhythms in health and disease” conference. Hosted at the University of Bergen the meeting runs from 28-30 August 2019 and will feature a number of international speakers.

For more information visit the conference website here:

https://www.uib.no/en/ultradian/126828/ultradian-conference-biological-rhythms-health-and-disease

 

 

We recently attended the European Congress of Endocrinology in Lyon which was a great meeting in a lovely city. We had the opportunity to present a method poster describing how we are validating the ULTRADIAN interstitial fluid data against conventional plasma methods. The initial data is looking great – click the link below to view the poster and see for yourselves some example profiles of cortisol, cortisone and aldosterone from four of our healthy volunteers!

P426_ECE_ULTRADIAN_POSTER

Thomas recently presented the bioRHYTHM Sampling around the clock study in poster form at BNA Festival of Neuroscience and won first prize in the Early Career Researcher Preregistration category – you can download and view the poster here!